MELK
MELK | |||||||||||||||||
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Pengidentifikasi | |||||||||||||||||
Alias | MELK, HPK38, maternal embryonic leucine zipper kinase | ||||||||||||||||
ID eksternal | OMIM: 607025 MGI: 106924 HomoloGene: 32111 GeneCards: MELK | ||||||||||||||||
EC number | 2.7.10.2 | ||||||||||||||||
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Ortolog | |||||||||||||||||
Spesies | Manusia | Tikus | |||||||||||||||
Entrez |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Lokasi (UCSC) | n/a | n/a | |||||||||||||||
Pencarian PubMed | [1] | [2] | |||||||||||||||
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Maternal embryonic leucine zipper kinase (MELK) adalah enzim yang pada manusia disandi oleh gen MELK.[3][4][5] MELK adalah serin/treonin kinase milik keluarga protein AMPK/snf1 kinase. MELK pertama kali diidentifikasi hadir sebagai mRNA maternal pada embrio tikus.[6] MELK telah terbukti terlibat dalam perkembangan melalui siklus sel, mungkin terkait dengan interaksinya dengan CDC25B.[7]
Ekspresi MELK meningkat pada sejumlah kanker dan merupakan target penelitian aktif untuk penghambatan farmakologis.[8]
Interaksi
MELK telah terbukti berinteraksi dengan CDC25B.[9]
Referensi
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. February 1996. doi:10.1093/dnares/3.1.17. PMID 8724849.
- ^ "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Molecular Reproduction and Development. 47 (2): 148–56. June 1997. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
- ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase".
- ^ "Expression of Melk, a new protein kinase, during early mouse development". Developmental Dynamics. 215 (4): 344–51. August 1999. doi:10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H. PMID 10417823.
- ^ "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation". The Journal of Cell Biology. 170 (3): 413–27. August 2005. doi:10.1083/jcb.200412115. PMC 2171475 . PMID 16061694.
- ^ "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers". Cancer Research. 65 (21): 9751–61. November 2005. doi:10.1158/0008-5472.CAN-04-4531. PMID 16266996.
- ^ "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. October 2002. doi:10.1038/sj.onc.1205870. PMID 12400006.
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