Protein-coding gene in the species Homo sapiens
| AQP8 |
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| Identifiers |
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| Aliases | AQP8, AQP-8, aquaporin 8 |
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| External IDs | OMIM: 603750; MGI: 1195271; HomoloGene: 68166; GeneCards: AQP8; OMA:AQP8 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 16 (human)[1] |
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| | Band | 16p12.1 | Start | 25,215,731 bp[1] |
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| End | 25,228,932 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7 F3|7 67.42 cM | Start | 123,061,514 bp[2] |
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| End | 123,067,227 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - mucosa of transverse colon
- body of pancreas
- mucosa of ileum
- rectum
- mucosa of sigmoid colon
- testicle
- pancreatic epithelial cell
- epithelium of colon
- islet of Langerhans
- cerebellar hemisphere
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| | Top expressed in | - left colon
- left lobe of liver
- lacrimal gland
- spermatocyte
- blastocyst
- yolk sac
- embryo
- parotid gland
- seminiferous tubule
- spermatid
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - water channel activity
- channel activity
| | Cellular component | - integral component of membrane
- plasma membrane
- apical part of cell
- integral component of plasma membrane
- membrane
- mitochondrion
- mitochondrial membranes
| | Biological process | - ion transmembrane transport
- cellular response to cAMP
- water transport
- transmembrane transport
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 16: 25.22 – 25.23 Mb | Chr 7: 123.06 – 123.07 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene.[5][6][7]
Aquaporin-8 (AQP-8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-8 mRNA is found in pancreas and colon but not other tissues.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000103375 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030762 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Koyama N, Ishibashi K, Kuwahara M, Inase N, Ichioka M, Sasaki S, Marumo F (Jan 1999). "Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene". Genomics. 54 (1): 169–72. doi:10.1006/geno.1998.5552. PMID 9806845.
- ^ Viggiano L, Rocchi M, Svelto M, Calamita G (Jul 1999). "Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12". Cytogenet Cell Genet. 84 (3–4): 208–10. doi:10.1159/000015260. PMID 10393433. S2CID 23854978.
- ^ a b "Entrez Gene: AQP8 aquaporin 8".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Harrington DJ, Adachi K, Royer WE (1997). "The high resolution crystal structure of deoxyhemoglobin S". J. Mol. Biol. 272 (3): 398–407. doi:10.1006/jmbi.1997.1253. PMID 9325099.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Fischer H, Stenling R, Rubio C, Lindblom A (2003). "Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors". BMC Physiol. 1: 1. doi:10.1186/1472-6793-1-1. PMC 32180. PMID 11231887.
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
- Wang S, Kallichanda N, Song W, et al. (2001). "Expression of aquaporin-8 in human placenta and chorioamniotic membranes: evidence of molecular mechanism for intramembranous amniotic fluid resorption". Am. J. Obstet. Gynecol. 185 (5): 1226–31. doi:10.1067/mob.2001.117971. PMID 11717661.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wang S, Chen J, Au KT, Ross MG (2003). "Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells". Am. J. Obstet. Gynecol. 188 (4): 997–1001. doi:10.1067/mob.2003.214. PMID 12712100.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zahn A, Moehle C, Langmann T, et al. (2007). "Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis". World J. Gastroenterol. 13 (11): 1687–95. doi:10.3748/wjg.v13.i11.1687. PMC 4146947. PMID 17461471.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
